"Give It 2 Me" received positive reviews from contemporary critics. The song became Madonna's thirty-ninth number-one single on the Billboard Hot Dance Club Play chart. It charted on the Billboard Hot 100 for one week, and reached a peak of fifty-seven only, due to limited radio play. The song topped the music charts in Hungary, the Netherlands and Spain, while it attained top-ten positions on the charts of many other European nations.
The music video featured Madonna recreating her look from the Elle magazine May covergirl photo shoot, and was directed by photographer Tom Munro. Williams had a guest appearance in the video. It received positive response for her retro-inspired look. Madonna performed "Give It 2 Me" on both the promotional tour for Hard Candy, and the 2008–09 Sticky & Sweet Tour, where she performed it as the final song of the concert. "Give It 2 Me" received a Grammy nomination in 2009 in the Best Dance Recording category. Wikipedia. Give It 2 Me